Tubocurarine and Pancuronium: A Pharmacokinetic View
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چکیده
منابع مشابه
Fade characteristics and onset times following administration of pancuronium, tubocurarine and a mixture of both agents.
The onset characteristics of pancuronium, tubocurarine and a mixture of these two neuromuscular blocking drugs were studied during the induction of neuromuscular blockade, using a train-of-four pattern of stimulation. Four characteristics of onset were defined: train-of-four fade = a reduction in the height of the fourth twitch greater than a reduction in the height of the first twitch; latent ...
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PA~CU~ONrOM B~OMIDE (Organon NA97) is a steroid compound non-depolarizing neuromuscular blocking agent, 1 synthesized by Hewett and Savage in 1964. Following extensive pharmacological studies in animals, Buckett and Bonta 2 suggested that this agent possessed properties similar to those of d-tubocurarine but with certain differences in side effects. Its potency is claimed to be about five times...
متن کاملA comparative evaluation of intubating doses of atracurium, d-tubocurarine, pancuronium and vecuronium in children.
To determine the onset and recovery times and haemodynamic effects of intubating doses of atracurium (0.4 mg.kg-1), d-tubocurarine (0.8 mg.kg-1), pancuronium (0.12 mg.kg-1), and vecuronium (0.07 mg.kg-1), sixty-seven children aged one to eight years were studied under halothane and nitrous oxide anaesthesia. The time to maximum twitch depression and the time to recovery to T1/Tc 25 per cent wer...
متن کاملThe kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium.
Equilibrium conditions of neurotransmitter concentration and receptor binding are never achieved during synaptic transmission at the neuromuscular junction. Thus, it is important to determine the binding kinetics of drugs that act this synapse. Previous determinations of the dissociation rate of (+)-tubocurarine have produced inconsistent results ranging from 0.1 to 4000/s. Here, we used a dire...
متن کاملEffect of atracurium, vecuronium, pancuronium and tubocurarine on renal sympathetic nerve activity in baroreceptor denervated dogs.
The mechanism of arterial hypotension induced by non-depolarizing neuromuscular blocking agents may be multifactorial and differ between drugs. The purpose of this study was to evaluate the effect of high-dose atracurium and equivalent doses of other non-depolarizing neuromuscular blocking agents on haemodynamic state and sympathetic nervous activity. In studies on 24 mongrel dogs anaesthetized...
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ژورنال
عنوان ژورنال: Anaesthesia and Intensive Care
سال: 1980
ISSN: 0310-057X,1448-0271
DOI: 10.1177/0310057x8000800102